Measurements in fundamental physics are becoming increasingly difficult. In particular, many high-precision measurements are now dealing with the intrinsic quantum mechanical noise of the detectors themselves. LIGO is an example: it is limited by Heisenberg uncertainty in the laser light. However, this quantum noise can in principle be engineered away by clever use of quantum resources. I will discuss these issues through some examples (cosmic neutrino detection, gravitational wave detection, and tests of quantum gravity), and offer some speculations on the practical and perhaps fundamental limitations on quantum engineering for measurements of this type.